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Comparable to sticking a note that says “SKIP” onto a page of a book – a reader will ignore this page but the book itself has not been changed.
Scientists have also formed a version of the guide RNA that consists of a single molecule, the single-guide RNA (sgRNA).
An endonuclease cuts in the middle of RNA or DNA, while an exonuclease cuts from the end of the strand. Genome engineering tools like Cas9 are endonucleases.