An ATP and IGI Functional Genomics Collaboration
Date published: Thursday, September 23, 2021
The Innovative Genomics Institute (IGI) and Apple Tree Partners (ATP) invite scientists affiliated with the University of California Berkeley (UC Berkeley) or University of California San Francisco (UCSF) to apply for an exciting opportunity to collaborate with the new Center for CRISPR Target Discovery (CCTD) as a primary investigator (PI) on projects aimed at accelerating the treatment and prevention of human disease through interrogation and validation of novel drug targets.
The Center for CRISPR Target Discovery is a state-of-the-art functional genomics laboratory created by IGI and the life sciences venture capital firm Apple Tree Partners (ATP) to use the power of CRISPR-based technologies to accelerate the exploration and validation of new biological targets that can be translated into novel therapeutics to answer unmet needs.
This RFA is extended to members of the UC Berkeley and UC San Francisco research community who have an interest in using CRISPR-based functional genomics for target validation and therapeutic applications. Successful applications will be focused on disease-related genetic target discovery, and applicants should have the intent to found a company based on project outcomes or to collaborate with ATP in their efforts to found a new commercial entity to develop these discoveries.
Projects accepted to the Center for CRISPR Target Discovery are envisaged to be 1 to 2 years long and will include comprehensive project support for experiments at the CCTD at IGI and in PI laboratories.
In-scope applications will propose the use of functional genomics approaches in mammalian cells and ex vivo systems that, if successful, will lead to the identification or validation of genomic targets to open new avenues to treat/prevent human disease. We also encourage applications that seek to establish or explore broader functional genomics-based biological platforms with discovery/therapeutic potential.
Here is how you, as a PI, will work with IGI and ATP on a Center for CRISPR Target Discovery project:
Applicants are encouraged to propose a comprehensive set of primary screen follow-up studies that can feature more sophisticated cell systems, arrayed screening approaches, etc., with the goal of obtaining a definitive determination of hit-disease connection within the time frame of the funding.
PIs must hold their primary or adjunct appointment at UC Berkeley or UC San Francisco. We are encourage researchers from non-dominant groups to apply, and hope to have an applicant pool that reflects the diversity of our California community.
The Center for CRISPR Target Discovery anticipates funding up to 6 projects throughout its overall 3-year duration period. The budget allowance is $250,000 total costs per year pro rata for a maximum of two years, with funding to begin Feb 1, 2022. If your proposed project has a duration of, for example, 12 months, 18 months, or 24 months, the budget outlined in your proposal could be up to $250k, $375k, and $500k total costs, respectively. The allowance of Year 2 funding will depend on progress during Year 1.
Candidates are asked to include in their application:
1) A 3-page project description (1,000-word limit, including figures and references) with:
2) A concise proposed budget
The total award (see above) can be used for PI, postdoc, and/or graduate student salaries, supplies, minor equipment, or other related research expenses, and should include indirect costs based on the PI’s institution rates. All expenditures must be allowable under, and comply with, applicable University of California policies.
3) Their CV
Applications are now closed.
Proposals will be reviewed by a CCTD Review Board. External experts, selected by the Review Board, will be called upon if necessary.
The peer-review process will be complete and applicants notified of funding decisions in early January, 2022.
Please email Lucie Bardet at firstname.lastname@example.org.