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Berkeley Initiative for Optimized Microbiome Editing (BIOME)
Genome editing for the microbial world
About BIOME
Microbes live in communities in, on, and around us, shaping human biology and the world through their collective behavior. An unbalanced human microbiome underlies a growing list of diseases, including cardiovascular disease, Alzheimer’s disease, and antibiotic-resistant infections. Microbes also influence the increasing greenhouse gas concentrations that threaten all life on Earth. The Berkeley Initiative for Optimized Microbiome Editing (BIOME) at the IGI is unlocking the power of CRISPR to understand microbial communities and precisely edit them in their natural environments. Our aim is to enable safe and wide-ranging solutions to currently intractable problems. Specifically, our research areas are:
- Cultivating and characterizing microbial communities at the systems level
- Developing technologies to edit natural microbial communities
- Editing microbial communities for positive human health, food production, and climate outcomes
Team
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Spencer Diamond, Ph.D.
P.I. Microbiome Modeling
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Rohan Sachdeva, Ph.D.
Director, Computational Infrastructure
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Ben Rubin, Ph.D.
P.I. Microbiome Editing Applications
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Jill Banfield, Ph.D.
Director, Microbiology
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Jennifer Doudna, Ph.D.
Founder & Chair of the IGI Governance Board
Audacious Project
Announced in April 2023, the IGI received $70M in funding through the Audacious Project, an initiative housed at TED, to apply precision genome editing to microbial communities for climate change and human health applications.
The work on this initiative will be led by the BIOME PIs in collaboration with UC Davis and UCSF to enable translation of these technologies to field and clinical studies. The initiative is targeting two initial applications: reducing methane emissions from livestock, and preventing childhood asthma.
Learn more about this initiative:
- IGI’s ‘Audacious’ New Frontier for CRISPR: Editing Microbiomes for Climate and Health (IGI)
- Can CRISPR Cut Methane Emissions From Cow Guts? (UC Davis)
- Editing Genes in the Microbiome to Prevent Disease (UCSF)
- Engineering Microbiomes with CRISPR to Improve Our Climate and Health (The Audacious Project)
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Key Publication
Species- and site-specific genome editing in complex bacterial communities
Rubin BE, Diamond S, Cress BF, Crits-Christoph A, Lou YC, Borges AL, Shivram H, He C, Xu M, Zhou Z, Smith SJ, Rovinsky R, Smock DCJ, Tang K, Owens TK, Krishnappa N, Sachdeva R, Barrangou R, Deutschbauer AM, Banfield JF, and Doudna JA. Nature Microbiology
(2021)Careers & Contact
- Find out about open positions in the Berkeley Initiative for Optimized Microbiome Editing on IGI's Careers page.
- For any inquiries about the Berkeley Initiative for Optimized Microbiome Editing's ongoing work or potential partnerships, please contact Brady Cress (cress@berkeley.edu), Spencer Diamond (sdiamond@berkeley.edu), or Ben Rubin (brubin@berkeley.edu).
- Lab webpages:
Funding
Funding for the Berkeley Initiative for Optimized Microbiome Editing comes from the Shurl & Kay Curci Foundation and anonymous donors though the Audacious Project, an initiative of TED.
