Advancing Genome Engineering

Unlocking the full potential of CRISPR genome editing requires continuous innovation.

We are committed to optimizing current tools, and developing new ones. Many antibiotics, enzymes, drugs, and research tools like CRISPR-Cas9 are the repurposed natural products of microbes. To discover novel molecules, the IGI gathers genetic information from thousands of previously unknown bacteria and archaea. We also need more options for safely and reliably delivering editing tools to agricultural crops and the parts of the human body that are harmed by mutations. The IGI is developing cross-cutting new approaches for the delivery of genome editing tools. We are building upon foundational CRISPR-Cas technologies to create more precise and powerful tools for manipulating the genome.


Principal Investigators


Research Projects


Published Papers

Key Goals

Develop new ways to deliver CRISPR components to specific cells and tissues
Analyze and enhance the performance of existing genome editing methods
Create new CRISPR-Cas technologies, from new Cas effectors to new functions
Red bone marrow cells

IGI Delivery Collective

The delivery challenge for genome editing therapies is the single greatest impediment to widespread use of CRISPR-based therapies for genetic diseases and beyond. The IGI Delivery Collective is a collaborative effort working to develop new technology that enables or improves access to therapeutic genome editing.

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