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Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A.

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A call for science-based review of the European court’s decision on gene-edited crops.

Urnov FD, Ronald PC, and Carroll D. Nature Biotechnology

Using forward genetics in Nicotiana benthamiana to uncover the immune signaling pathway mediating recognition of the Xanthomonas perforans effector XopJ4.

Schultink A, Qi T, Bally J, and Staskawicz B. New Phytologist

Atlastins remodel the endoplasmic reticulum for selective autophagy.

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Emerging strategies for genome editing in the brain.

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CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window.

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CRISPR–Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.

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Simultaneous CRISPR/Cas9-mediated editing of cassava eIF4E isoforms nCBP-1 and nCBP-2 reduces cassava brown streak disease symptom severity and incidence.

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Mapping the genetic landscape of human cells.

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In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway.

Wienert B, Shin J, Zelin E, Pestal K, and Corn JE. PLoS Biology

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Reprogramming human T cell function and specificity with non-viral genome targeting.

Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, and Marson A. Nature

Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis.

Crits-Christoph A, Diamond S, Butterfield CN, Thomas BC, and Banfield JF. Nature

Using CRISPR as a gene editing tool for validating adaptive gene function in tree landscape genomics.

Fernandez I Marti A and Dodd RS. Frontiers in Ecology and Evolution

Consequences of resistance evolution in a Cas9-based sex conversion-suppression gene drive for insect pest management.

KaramiNejadRanjbar M, Eckermann KN, Ahmed HMM, Sánchez C HM, Dippel S, Marshall JM, and Wimmer EA. PNAS

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Synthetically engineered Medea gene drive system in the worldwide crop pest Drosophila suzukii.

Buchman A, Marshall JM, Ostrovski D, Yang T, and Akbari OS. PNAS. Preprint (free to read).

BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes.

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Roq1 mediates recognition of the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1.

Schultink A, Qi T, Lee A, Steinbrenner AD, and Staskawicz B. The Plant Journal

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E pluribus unum (“out of many, one”): CRISPR modeling of myeloid expansion.

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Production of purified CasRNPs for efficacious genome editing.

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Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.

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Discovery of stimulation-responsive immune enhancers with CRISPR activation.

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Between-region genetic divergence reflects the mode and tempo of tumor evolution.

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