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© 2017 Barbara Ries

Mutations in single genes cause more than 5000 human diseases.

Doctors can only treat the symptoms of genetic disease and patients often need to take non-curative drugs for their entire life. Scientists have known the cause of many genetic disorders for years, but until now there has been no way to cure them. The IGI aims to use the ‘molecular scalpel’ Cas9 to permanently correct disease-causing mutations in cells, animal models, and eventually human patients. Our first major goals are therapies to treat sickle cell disease and a rare familial autoimmune disorder.

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Principal Investigators

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Research Projects

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Published Papers

Hand holding slides with sections of tissue. © Noah Berger 2016

Key Goals

Work to understand the genetic basis of complex diseases
Identify new disease-modifying genes
Find ways to prevent disease
Develop CRISPR-based therapies for diseases that affect underserved populations

Latest News

Cell infected with SARS-CoV-2, with filopodium.
Press ReleasesCOVID-19

COVID-19 Relies on Cell’s ‘Master Regulators’ for Survival

Saliva study
Press ReleasesCOVID-19

IGI Launches Trial of Saliva Test for COVID-19

robotic lab equipment
IGI NewsCOVID-19

Robotic Pipeline Increases Capacity of the IGI COVID-19 Diagnostic Testing Lab

SARS-CoV-2 microgram secondary
Press ReleasesCOVID-19

IGI Awards $1 Million to COVID-19 Rapid Response Research Projects

Utility workers
Press ReleasesCOVID-19

IGI Takes COVID-19 Testing to Utility Workers, Underserved

IGI NewsCOVID-19

LGR Awards Seed Funding to COVID-19 Projects at UC Berkeley and UCSF

IGI NewsCOVID-19

IGI Scientists Examine Accuracy of Coronavirus Antibody Tests

IGI NewsCOVID-19

Shurl and Kay Curci Foundation Gives $1.25 Million to IGI COVID-19 Response Effort

COVID-19/globe merge
IGI NewsCOVID-19

IGI Launches Major Automated COVID-19 Diagnostic Testing Initiative

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