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The IGI is working to make CRISPR the standard of care for all genetic diseases.

Mutations in single genes cause more than 5,000 human diseases. Scientists have known the cause of many genetic disorders for years, but until now there has been no way to treat them. The IGI aims to use CRISPR-based treatments to correct disease-causing mutations in cells, animal models, and eventually human patients.

Hand holding slides with sections of tissue. © Noah Berger 2016

Key Goals

Discovery: Use CRISPR screens and machine learning to expand our understanding of the genetic basis of complex diseases and identify new therapeutic targets
Development: Streamline the creation of new CRISPR-based therapies and diagnostics for neglected diseases and areas of high unmet need
Translation: Accelerate the process of bringing accessible and scalable CRISPR cures from the lab bench to clinic
Linda in CTG

Center for Translational Genomics

The IGI Center for Translational Genomics (CTG) is a first-of-its-kind innovation hub for gene-editing research and development of targeted treatments for intractable genetic diseases. The CTG's aim is to accelerate the timeline from a diagnosis to a cure, and eventually provide customized treatments to individuals living with these conditions.

Flagship Projects

Exterior photo of the IGI Building taken from Berkeley Way West

Danaher-IGI Beacon for CRISPR Cures

The Beacon for CRISPR Cures aims to create a roadmap for rapidly developing genome-editing therapies.

The IGI is partnering with Danaher, a leading global life sciences and diagnostics innovator, to create a new collaborative center with the goal of scaling up and accelerating the development of CRISPR-based cures for rare diseases and beyond.

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Sickle Cell Initiative

We are advancing the first not-for-profit clinical trial of a genomic medicine for sickle cell disease.

IGI investigators are working with a consortium of researchers at UC Berkeley, UCSF, and UCLA on a clinical trial using CRISPR technology developed at the IGI to directly correct the mutation that causes sickle cell disease Our holistic approach to sickle cell disease includes partnering with the sickle cell community, public education, and finding new models to make therapies accessible to those who need it. 

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Korey Sop IGI Clinical Lab

Interventional Genomics

We are creating the diagnostics and tools to enable the future of genomic medicine.

Researchers in the IGI Clinical Laboratory are developing critical assays to assess the safety and efficacy of new genome-editing therapies in clinical trials at a molecular level, and are developing the necessary tools and infrastructure to enable a future in which interventional genomics becomes a standard practice in hospitals around the world.

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