Peter Glazer Seminar: Genome Editing in Mice with PNAs

While CRISPR-Cas9 has brought genome editing to the masses, it’s not the only genome editor in town. Dr. Peter Glazer will discuss his work to develop peptide nucleic acids (PNAs) into a robust tool for targeted DNA engineering. PNAs bind to DNA double helices to form a triple helix, recruiting DNA repair proteins and facilitating incorporation of new DNA segments. By delivering PNAs and donor DNA to hematopoietic stem/progenitor cells (HSPCs) in biodegradable nanoparticles, Glazer and his team are able to correct mutations in the beta-globin gene. This intriguing approach is an attractive alternative to genome editing methods that involve DNA cleavage.

Genome Editing in Adult and Fetal Mice by PNA Nanoparticles

Dr. Peter Glazer

Professor, Therapeutic Radiology & Genetics

Yale University School of Medicine