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COVID-19 Research at IGI, SARS-CoV-2 virus

COVID-19 Research Projects

We are working rapidly to better understand, detect, track, and develop therapies for the novel coronavirus through a range of COVID-19 research projects.

 

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Overview

The IGI is accelerating research efforts to fight the COVID-19 pandemic. We have awarded over $2 million in funding to new COVID-19 research projects through our Rapid Response Research (RRR) fund and the Laboratory for Genomics Research (LGR) Excellence in Research Award (ERA). Because of the urgency of this public health crisis, we are supporting projects that will yield results in just 6–12 months. 

These research projects span a variety of approaches aimed at quickly gaining a better understanding of SARS-CoV-2 and the COVID-19 pandemic to track its spread, develop new diagnostic and therapeutic approaches, and to address the impacts of the pandemic on science.

We will update this page as projects progress.

Our COVID-19 Research

Diagnostics

Epidemiology, Surveillance, and Viral Sequencing

SARS-CoV-2 Virology, Life Cycle, and Pathogenesis

  • Discovering and targeting the RNA structural code underlying SARS-CoV-2 life cycle.
    Hani Goodarzi, UCSF. Read more >
  • Identification of host-dependency factors for SARS-CoV-2.
    Nevan Krogan and Melanie Ott, UCSF. Read more >
  • Transcriptomic features of cellular and tissue pathogenesis of SARS-CoV-2 infection in human tissues.
    Bruce Wang, UCSF
  • Exploring SARS-CoV-2 viruses using CRISPR-based yeast recombineering.
    Raul Andino and Hiten Madhani, UCSF. Read more >
  • Inhibiting SARS-CoV-2 virulence protein function using functional genomics and structural biology.
    Britt Glaunsinger, UC Berkeley. Read more >

Social Science

  • Virtual mentoring: Impacts of COVID-19 on the next generation of the scientific workforce.
    Laleh Coté, LBNL & UC Berkeley; Anne Baranger, UC Berkeley; and Colette Flood, LBNL.
    Read more >
    – Research Spotlight: Laleh Coté on Virtual Mentoring 

     

Structural Biology and Therapeutic Targets

  • Structural studies of the COVID-19 replication/transcription holo-complex.
    Eva Nogales, UC Berkeley. Read more >
  • The QCRG structural consortium: targeting the host-pathogen interface.
    Oren Rosenberg and Kliment Verba, UCSF. Read more >
  • Determining factors that inhibit the interaction between COVID-19 and its receptor on lung epithelial cells.
    Robert Stroud, UCSF. Read more >

Vaccines and Therapeutics

  • Epigenome editing: a new prophylactic SARS-CoV-2 therapeutic.
    Luke Gilbert, UCSF and Jonathan Weissman, Whitehead Institute. Read more >
  • A Cas9-based shuttle enhancing cellular import and nuclear localization of plasmid DNA as an adjuvant of non-viral SARS-CoV-2 DNA vaccines entering human trials.
    Alex Marson, UCSF and Ross Wilson, UC Berkeley. Read more >
  • Screening for small molecule inhibitors of SARS-CoV-2 enzymes.
    Dan Nomura, Jamie Cate, et al., UC Berkeley. Read more >
  • Development of antisense oligonucleotide therapeutics for COVID-19.
    Anders Näär, UC Berkeley. Read more >

Hear From Our Researchers

Liana Lareau
Assistant Professor of Bioengineering 

 

Britt Glaunsinger
Professor of Molecular & Cell Biology/Plant & Microbial Biology

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