We are developing technology to quickly make multiple genetic changes to laboratory organisms.
The heart of this research program is to overturn the existing one-gene-at-a-time paradigm for probing gene function in organismal model studies, and to push the envelope for understanding genetic interaction in vivo. We will genetically modify organismal models using a high-throughput CRISPR-based platform suitable for interrogating pathways. This platform will allow the interrogation of thousands of targeted gene combinations in parallel in whole organism models. A high-throughput, targeted, multi-mutation approach has never been accomplished in any organismal model and if successful, our strategy will revolutionize the development of genetically engineered complex organismal models.
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