SLC19A1 transports immunoreactive cyclic dinucleotides.

Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, and Raulet DH. Nature

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells.

Mapping the genetic landscape of human cells.

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.

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Discovery of stimulation-responsive immune enhancers with CRISPR activation.

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A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response.

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

Cornerstones of CRISPR-Cas in drug discovery and therapy.