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Scientist hands pipetting in a tissue culture hood. © Steve Babuljak 2016

Research

Research Projects

Cascade and Cas3 protein structures

Developing CRISPR-Cas3 technology for large-scale genome manipulation

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Electron micrograph of herpesviruses

Development and engineering of gammaherpesviruses for delivery of CRISPR-Cas9 reagents

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Engineering exosomes to deliver CRISPR-Cas9 for genome editing in target cells and tissues

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Pan-AAV receptor mediated viral delivery to improve efficiency of CRISPR-based systems in vivo

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close-up depiction of DNA

Decoding the impact of silent mutations in disease

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radiation warning sign

Radiation protection and treatment with CRISPRi and CRISPRa

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Exploring the underlying mechanisms of plant immunity to viruses

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Microscope image of cancer cells that have been colored blue

CRISPR genetic screens to accelerate cancer therapies

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Rice plant in a field

Establishment of a novel tissue culture-free CRISPR-Cas9 RNP delivery system for efficient genome editing in rice

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Image of fluorescent human neurons

Identifying therapeutic targets for neurodegenerative diseases by CRISPRi screens in iPSC-derived neurons

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Squirrel brain cells with glowing red fluorescent mitochondria

Genomic editing of cytoprotective variants evolved in resilient organisms

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Red blood cells floating through artery

Discoveries and therapies for blood disorders

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Developing methods to precisely understand and control Cas9 and DNA repair outcomes

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Unlocking the hidden architecture of complex genetic interactions

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Red circles with red fluorescent dots scattered within them

Genome editing in plants with gold nanoparticles

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