Non-homologous end joining (NHEJ)

A way for a cell to repair a break in its DNA by attaching the free DNA ends. This pathway is “sloppier” than homology-directed repair, and often results in the random addition or removal of nucleotides around the site of the DNA break, causing insertions or deletions in the genetic code. In genome engineering, this allows scientists to stop a gene from working (similar to removing a page from the middle of an instruction manual).

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