David Nguyen

David Nguyen is an Assistant Professor of Medicine at the University of California San Francisco, Department of Medicine & Division of Infectious Diseases. He is a physician-scientist studying applications of genome editing in the immune system as applied to understanding and correcting mutations causing primary immunodeficiency (PID). His laboratory is based at the University of California, Berkeley within the IGI and the Center for Translational Genomics. 

The Nguyen lab focuses on three unmet needs for helping patients with PID diseases: (i) genome engineering in primary human cells to identify and diagnose patient-specific PID mutations, (ii) functional CRISPR screens to understand and predict how PID mutations impact immune cell behavior, and (iii) developing novel gene editing technologies for correcting pathogenic mutations in the immune and blood (hematopoietic) system – including PIDs and hemoglobinopathies. David is also an attending physician at UCSF with the adult infectious diseases service and immunology clinic, where he specializes in preventing and treating infections in patients with complex genetic immune defects.