CRISPR-Cas9 is a valuable new tool for high-throughput screening. Screens can be designed to generate gene knockouts, repress genes, or activate them. Libraries of guide RNAs targeting tens of thousands of sites across the genome are introduced into cells to tease apart the functions of different genes and regions of DNA that regulate gene expression. We are collaborating with basic researchers and biotechnology companies to perform genome-wide CRISPR screens in a variety of cell types to identify genes involved in many disease pathways. We will then test candidate genes as targets for clinical drug development. CRISPR screens let us explore a wide range of disease targets, including immune conditions and cancer.