The IGI's cancer research integrates two diverse fields – population genetics and cancer genomics. We hope to elucidate the evolutionary principles underlying the genome evolution of cancer cells during cancer progression, metastasis, and drug resistance. This research will help scientists and medical professionals understand how and why cancer evolves so quickly. By understanding the role of cell mutation rates in the spread of cancer, we can develop models that may lead to viable cancer treatments.
Between-region genetic divergence reflects the mode and tempo of tumor evolution.
Sun R, Hu Z, Sottoriva A, Graham TA, Harpak A, Ma Z, Fischer JM, Shibata D, and Curtis C. Nature Genetics (2017).
A population genetics perspective on the determinants of intra-tumor heterogeneity.
Hu Z, Sun R, and Curtis C. Biochimica et Biophysica Acta (2017).