We are using cutting-edge techniques to understand the proteins that make up the plant nuclear envelope, a membrane associated with multiple genetic disorders.
The nuclear envelope is a hallmark of the eukaryotic cell. Emerging evidence suggests that the nuclear envelope is also a critical communication interface that translates information from the cell periphery into nuclear activity. Mutations in nuclear envelope constituents are associated with a myriad of genetic disorders in eukaryotic organisms, the list of which is ever expanding.
Despite the emerging role of the nuclear envelope as a key structural and signaling platform, it has been the least understood membrane compartment in plants. By combining the power of proximity labeling technology, label-free quantitative proteomics, and ratiometric analysis, we aim to understand the protein landscape of the plant nuclear envelope and fundamental biological principles underlying this critical membrane compartment in plants.
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